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We retrospectively studied a cohort of 178 patients with clinicopathologic features suggestive of IIM with the exclusion of inclusion body myositis. At the end of follow-up, 156 of 178 cases were still categorized as IIM: pure dermatomyositis, n =44; pure polymyositis, n =14; overlap myositis, n =68; necrotizing autoimmune myopathy, n =8; cancer-associated myositis, n =18; and unclassified IIM, n =4. The diagnosis of IIM was ruled out in the 22 remaining cases. Pathologic dermatomyositis was the most frequent histologic picture in all serologic subsets of IIM, with the exception of patients with anti-Ku or anti-SRP autoantibodies, suggesting that it supports the histologic diagnosis of pure dermatomyositis, but also myositis. Unspecified myositis was the second most frequent histologic pattern. |
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